Erendra Manandhar, Ph.D.

Departments

Education

  • Ph.D.,University of Southern Mississippi, 2014
  • M.Sc., Tribhuvan University, 2003 (Nepal)
  • B.Sc., Tribhuvan University, 2001 (Nepal)

Courses

  • Organic Chemistry
  • General Chemistry

Biography

Erendra Manandhar, Ph.D., obtained his B.Sc. in chemistry and M.Sc. in Organic Chemistry with his thesis in Natural Product of Chemistry from Tribhuvan University, Kathmandu, Nepal. He worked as a lecturer in the Chemistry Department of Tribhuvan University and undergraduate colleges affiliated with Tribhuvan University from 2004 to 2007. He also worked in Japan for two years as an associate researcher in the pharmaceutical department at Kumamoto University and Kumamoto Health Science University. He obtained his Ph.D. in Supramolecular Chemistry at the University of Southern Mississippi. His Ph.D. research focused on the synthesis of fluorescent/colorimetric chemosensors for simultaneous detection of metal ions and anions and their application in live cell imaging in eukaryotic and bacterial cells.

After earning his Ph.D., Manandhar worked as a Postdoctoral Research Associate at the University of Akron, where his research centered on the prophyrin and Naphthalenediimide synthesis, self-assembly and Organic Photovoltaic. He continued his post-doctoral research at the Polymer Science Department on the coordination driven self-assembly of terpyridine with metal ions into metallo-macrocyles and its molecular fusion and fission.

In August 2022, Manandhar joined St. Mary’s University as an Assistant Professor of Chemistry. Prior to St. Mary’s, he was an Assistant Professor at Columbia State Community College from 2021 to 2022 and Visiting Assistant Professor at Berea College for three years from 2018-2021. His current research interests are in the areas of molecular recognition, self-assembly and covalent organic cages. In particular, he is interested in the terpyridine based macrocycles as molecular host for proteins and various carcinogenic compounds as well as the development of water-soluble molecular sensors by incorporating sugar groups addressing the water solubility issues essential for the sensors applications in biology and environment.

Publications

Zhang, Z.; Bai, Q.; Manandhar, E.; Zeng, Y.; Wu, T.; Wang, M.; Yao, L.Y.; Newkome, G. R.; Wang, Pingshan.; Xie, T. Z.; Supramolecular cuboctahedra with aggregation-induced emission enhancement and external binding ability. Chemical Science, 2022, 13(20), 5999-6007.

Manandhar, E.; Johnson, D. G. A.; Watson, W. M.; Dickerson, S.D.; Sahukhal, G.S.; Elasri, M.O.; Fronczek, F.; Cragg, P. J.; Wallace, K. J., Detection of Ferric ions in a gram-positive bacterium cell: staphylococcus aureus. Journal of Coordination Chemistry, 2021, 74 (1-3), 380-401.

Khattri R.; Morris D.; Bilinovich S.; Manandhar E.; Napper K.; Sweet J.; Modarelli D.; Leeper T.; Identifying ortholog selective fragment molecules for bacterial glutaredoxins by NMR and affinity enhancement by modification with an acrylamide warhead. Molecules. 2020, 25 (1), 147.

Wallace, K. J.; Jones, W, S.; Jones, A. G.; Manandhar, E.; Chemodosimeters and chemoreactands for sensing ferric ions. Supramol. Chem. 2018, 30, 353-383.

Xie, T. Z.; Wu, X.; Endres, K.; Guo, Z.; Lu, X.; Li, J.; Manandhar, E.; Ludlow, J.; Moorefield, C. N.; Saunders, M. J.; Wesdemiotis, C.,; Newkome, G. R., Supercharged Precise Megametallodendrimers via A Single-Step, Quantitative Assembly Process. J. Am. Chem. Soc.2017, 139(44), 15652-15655.

Yao, Y.; Chakraborti, S.; Zhu, S.; Endres, K. J.; Xie, T. Z.; Hong, W.; Manandhar, E.; Moorefield, C. N.; Wesdimeotis, C.; Newkome, G. R., Stepwise, multicomponent assembly of a molecular trapezoid possessing three different metals. Chem. Commun. 2017, 53 (31), 8038-8041.

Taraboletti, A.; Walker, T.; Avila, R.; Huang, H.; Caporoso, J.; Manandhar, E.; Leeper, T.C.; Modarelli, D. A.; Medicetty, S.; Shriver, S. P., Cuprizone Intoxication Induces Cell Intrinsic Alterations in Oligodendrocyte Metabolism Independent of Copper Chelation. Biochemistry. 2017, 56, 1518-1528.

Manandhar, E.; Cragg, P. J.; Wallace, K. J., Detection of Zn(II) ions by fluorescent pyrene-derived molecular probes. Supramol. Chem. 2014, 26, 141-150.

Manandhar, E.; Wallace, K. J., Host-guest chemistry of pyrene-based molecular receptors. Inorg. Chim. Acta2012, 381, 15-43.

Manandhar, E.; Broome, J. H.; Myrick, J.; Lagrone, W.; Cragg, P. J.; Wallace, K. J., A pyrene-based fluorescent sensor for Zn2+ ions: a molecular butterfly. Chem. Commun. 2011, 47(31), 8796-8798.

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